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LEUROSINE

Product Name
LEUROSINE
CAS No.
23360-92-1
Chemical Name
LEUROSINE
Synonyms
amotin;LEUROSINE;nsc-528004;Vinleurosine;Vincristine EP Impurity F;Vincristine EP Impurity F (Leurosine);4'-Deoxy-3',4'-epoxyvincaleucoblastine, 9CI;(3'R,4'S)-3',4'-Oxy-4'-deoxyvincaleukoblastine;Vincristine Impurity 6(Vincristine EP Impurity F);4′-deoxy-3′α,4′α-epoxyvincaleukoblastine(leurosine)
CBNumber
CB4205283
Molecular Formula
C46H56N4O9
Formula Weight
808.97
MOL File
23360-92-1.mol
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LEUROSINE Property

Melting point:
202-205℃
Density 
1.39
pka
11.36±0.60(Predicted)
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Safety

RIDADR 
1544
HazardClass 
6.1(a)
PackingGroup 
II
Hazardous Substances Data
23360-92-1(Hazardous Substances Data)
Toxicity
dog,LDLo,intraperitoneal,12mg/kg (12mg/kg),GASTROINTESTINAL: NAUSEA OR VOMITINGGASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA",Eksperimental'naya Onkologiya. Experimental Oncology. Vol. 9(5), Pg. 76, 1987.
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
V314520
Product name
Vinleurosine
Packaging
10mg
Price
$1320
Updated
2021/12/16
Arctom
Product number
CFN90466
Product name
Vinleurosine
Purity
≥98%
Packaging
10mg
Price
$833
Updated
2021/12/16
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LEUROSINE Chemical Properties,Usage,Production

Description

Vinqa rosea yields this complex dimeric alkaloid which forms colourless crystals that are best purified by recrystallization from acetonitrile. It crystallizes with 8 moles of H20 and loses solvent when heated at In-5°C. It is also dextro? rotatory with [α]26D + n° (CHCI3)’ A crystalline SUlphate is known which has m.p. 238-242°C (dec.) and [α]D - 8.3° (MeOH). The N(b)-oxide is identical with pleurosine (q.v.).

Uses

Antineoplastic.

Uses

Vinleurosine is an antitumor compound derived from Vinca Rosea.

Definition

ChEBI: Leurosine is a vinca alkaloid.

References

Svoboda., J. Amer. Pharm. Assoc., 47,834 (1959)
Neuss et al., J. Amer. Chern. Soc., 81,4754 (1959)
Revised structure:
Neuss et al., Tetrahedron Lett., 783 (1968)

LEUROSINE Preparation Products And Raw materials

Raw materials

Preparation Products

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LEUROSINE Suppliers

Canada 1 CHINA 53 India 1 United States 6 Global 61
EMMX Biotechnology LLC
Tel
888-539-0666
Fax
888-539-0666
Email
info@emmx.com
Country
United States
ProdList
8449
Advantage
60
Standardpharm Co. Ltd.
Tel
86-714-3992388
Email
overseasales1@yongstandards.com
Country
United States
ProdList
14336
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354
Email
support@targetmol.com
Country
United States
ProdList
19973
Advantage
58
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View Lastest Price from LEUROSINE manufacturers

Career Henan Chemical Co
Product
LEUROSINE 23360-92-1
Price
US $0.01/KG
Min. Order
1KG
Purity
98%; 99%
Supply Ability
500g;1kg； 25kg
Release date
2020-01-09

23360-92-1, LEUROSINERelated Search:

VincristineM1 4'-Deoxy Vincristine N-Desmethylvinblastine Vinorelbine EP Impurity G Aspidospermidine-3-carboxylic acid, 4-(acetyloxy)-6,7-didehydro-15-[(6R,8S)-4-ethyl-1,3,6,7,8,9-hexahydro-8-(methoxycarbonyl)-2-oxido-2,6-methano-2H-azecino[4,3-b]indol-8-yl]-3-hydroxy-16-methoxy-1-methyl-, methyl ester, (2β,3β,4β,5α,12R,19α)- 4-Desacetyl Vinblastine 3',4'-Anhydrovinblastine Vinorelbine EP Impurity H Cophylline desacetylnavelbine Vinorelbine EP Impurity F VINBLASTINE (2R,3R)-3-AMINO-2-HYDROXYHEXANOIC ACID LEUROSINE (R)-3-AMINO-4-(3-METHYLPHENYL)BUTANOIC ACID HYDROCHLORIDE 3-AMINO-4-(4-METHOXY-PHENYL)-BUTYRIC ACID (R)-3-AMINO-4-(4-METHOXYPHENYL)BUTANOIC ACID (2S,3R)-3-AMINO-2-HYDROXY-4-PHENYLBUTYRIC ACID HYDROCHLORIDE

  • 4’-deoxy-3’,4’-epoxy-,(3’-alpha,4’-alpha)-vincaleukoblastin
  • 4’-deoxy-3’,4’-epoxy-,(3’alpha,4’alpha)-vincaleukoblastin
  • amotin
  • LEUROSINE
  • Vincristine EP Impurity F
  • Vinorelbine EP Impurity E/Leurosine/4b-Acetoxy-3,4epoxy-3-hydroxy-16-methoxy-(4 H)-vincaleukoblast-6-ene-23,22dioic Acid Dimethyl Ester
  • Vincristine EP Impurity F (Leurosine)
  • nsc-528004
  • Vinleurosine
  • 4b-Acetoxy-3,4epoxy-3-hydroxy-16-methoxy-(4 H)-vincaleukoblast-6-ene-23,22dioic Acid Dimethyl Ester
  • (3'R,4'S)-3',4'-Oxy-4'-deoxyvincaleukoblastine
  • (3'alpha,4'alpha)-4'-Deoxy-3',4'-epoxyvincaleukoblastine
  • 4'-Deoxy-3',4'-epoxyvincaleucoblastine, 9CI
  • Vincristine Impurity 6(Vincristine EP Impurity F)
  • Vincaleukoblastine,4'-deoxy-3',4'-epoxy-, (3'a,4'a)-
  • Vincaleukoblastine, 4'-deoxy-3',4'-epoxy-, (3'α,4'α)-
  • 4′-deoxy-3′α,4′α-epoxyvincaleukoblastine(leurosine)
  • methyl(3aR,4R,5S,5aR,10bR,13aR)-4-(acetyloxy)-3a-ethyl-9-[(1aS,11S,13S,13aR)-1a-ethyl-11-(methoxycarbonyl)-1a,4,5,10,11,12,13,13a-octahydro-2H-3,13-methano-oxireno[9,10]azacycloundecino[5,4-b]indol-11-yl]-5-hydroxy-8-methoxy-6-methyl-3a,4,5,5a,6,11,12,13a-octahydro-1H-indolizino[8,1-cd]carbazole-5-carboxylate(leurosine)
  • Vincristine EP Impurity F(Vinorelbine EP Impurity E)
  • 23360-92-1
  • C46H58N4O13S